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OSIMERTINIB INTERMEDIATE 1

N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine

CAS: 1421372-94-2

Molecular Formula: C20H16FN5O3

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OSIMERTINIB INTERMEDIATE 1 - Names and Identifiers

Name N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine
Synonyms AZD9291 1
OSIMERTINIB INTERMEDIATE 1
N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine
2-PyriMidinaMine, N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methyl-1H-indol-3-yl)-
(4-Fluoro-2-methoxy-5-nitro-phenyl)-[4-(1-methyl-1h-indol-3-yl)-pyrimidin-2-yl]-amine
N-(4-fluoro-2-methoxy-5-nitrophenyl)- 4-(1-methylindol-3-yl)pyrimidin-2-amine(AZD9291 Intermediate 2)
CAS 1421372-94-2
EINECS 806-156-3

OSIMERTINIB INTERMEDIATE 1 - Physico-chemical Properties

Molecular FormulaC20H16FN5O3
Molar Mass393.37
Density1.41±0.1 g/cm3(Predicted)
Melting Point>250°C (dec.)
Boling Point639.3±65.0 °C(Predicted)
Solubility DMSO (Slightly, Heated)
AppearanceForm Solid, color Light Yellow to Yellow
ColorLight Yellow to Yellow
pKa2.02±0.10(Predicted)
Storage Condition2-8°C(protect from light)
UseUses This product is used as a reagent to synthesize dihydropyrroloquinoline derivatives with anti-cancer activity and as an EGFR regulator to inhibit L858R/T790M.

OSIMERTINIB INTERMEDIATE 1 - Upstream Downstream Industry

Raw Materials3-(2-chloropyriMidin-4-yl)-1-Methylindole
4-fluoro-2-Methoxy-5-nitroaniline
1-Methylindole
2,4-DIFLUORO-5-NITROANILINE
3-(2-chloropyriMidin-4-yl)-1H-indole
4-FLUORO-2-METHOXYANILINE
Indole
2,4-Difluoroaniline
Downstream ProductsAZ 7550

OSIMERTINIB INTERMEDIATE 1 - Nature

Solubility DMSO (Slightly, Heated)
Last Update：2024-04-10 22:29:15
OSIMERTINIB INTERMEDIATE 1
Supplier List
Shanghai Macklin Biochemical Co., Ltd
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Visit Supplier Webpage Request for quotation
CAS: 1421372-94-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Request for quotation
CAS: 1421372-94-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CHEMBSF (Shanghai) Biomedical Technology Co., Ltd
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Product Name: N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Request for quotation
CAS: 1421372-94-2
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Request for quotation
CAS: 1421372-94-2
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Wechat: chemical6666 
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Visit Supplier Webpage Request for quotation
CAS: 1421372-94-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: 2-Pyrimidinamine, N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)- Visit Supplier Webpage Request for quotation
CAS: 1421372-94-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
OSIMERTINIB INTERMEDIATE 1
3-甲氧基-2-哌啶酮
2-氨基-4-甲氧基-5-(3-吗啉代丙氧基)苯甲酰胺
CALCIUM PHOSPHATE, HYDROXIDE PURIFIED
3-氨基-1H-吡咯-2,4-二甲酸2,4-二乙酯
2-硝基-4-甲氧基-6-溴苯胺
2-[双(3,5-二-叔丁基-4-甲氧苯基)膦基]苯甲醛
VINYL BEHENATE
2-((叔丁氧羰基)氨基)-3-乙氧基-3-氧代丙酸
2-[环丙基-[(2-甲基丙-2-基)氧基羰基]氨基]乙酸
Raw Materials for OSIMERTINIB INTERMEDIATE 1
3-(2-chloropyriMidin-4-yl)-1-Methylindole
1-Methylindole
3-(2-chloropyriMidin-4-yl)-1H-indole
4-FLUORO-2-METHOXYANILINE
Indole
Downstream Products for OSIMERTINIB INTERMEDIATE 1
AZ 7550
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